Farmaci Genotossici § Farmaci Cancerogeni § Carcinogenic Drugs § Genotoxic Drugs

Questo sito esiste oggi, grazie a l'impegno, lo studio, la dedizione, l'etica professionale, la passione, l'amore per il prossimo, di molte persone che hanno impiegato i loro anni di vita per la verità scientifica nel rispetto del genere umano.

Il sito oggi è la rappresentazione dello studio scientifico delle seguenti fonti (in ordine di inserimento):

I.M. Asher, C. Zervos. a) "A guide to testing priorities" in: Proceeding of Symposium on Structural correlates of carcinogenesis and mutagenesis. Eds Office of Science FDA, HEW-Publication n. 781046 (1977). b) Idem, "Structural correlates of carcinogenicity and mutagenicity and potential regulatory applications" in: Envirom. Health Chemistry. Ed. J. McKinney (Ann Arbor Science, 1981) cap. 29, p. 633

Schmähl, p. 144

H. S. Rosenkranz et al. in: IARC Long-term and Short-term Assays for Carcinogens: a critical appraisal. Ed.R.Montesano et al. (IARC Scientific Publ. n. 83, Lyon 1986)

G. M. Cramer et al., "Estimation of toxic hazards. A decision tree ap­proach", Fd. Cosmet. Toxicol. 16. 255 (1978); K. Enslein, P. N. Craig, "Carcinogenesis: A Predictive Structure-Acti­vity Model", J. Toxicol. Envirom. Health 10. 521 (1982); K. Enslein et al., "Mutagenicity (Ames): A Structure-Activity Model", Terat. Carcin. Mutag. 3, 503 (1983); G. Klopman, J. Am. Chem. Soc. 106.7315 (1984); V. Veljkovic, A theoretical approach to the preselection of carcino­gens and chemical carcinogenesis (Gordon and Breach, Science Publ., New York 1981); D.F.V.Lewis et. al., in: Drug Metabolism. From Molecules to Man. Ed. D. J. Benford et. al. (Taylor and Francis, London 1987) p. 369

E. Crouch, R. Wilson, Risk Analysis 1 (1) 47 (1981)

g. s. Chimica Industria 67 (10) 603 (1985)

I.C. Munro et al., Toxicol. Appl. Pharmacol. 32, 513 (1975); J. Sims, A. G. Renvick, ibidem 67 (1) 132 (1983)

G. L. Gatti, F.Toffoli, Boll. Chim. Farmac. 177, 69 (1978)

G. Bonadonna et. al., Una sfida possibile (Rizzoli 1988) 2° cap.

E. Adami, Farmacologia e Farmacoterapia. 5a ed. (Istituto Editoriale Cisalpino, Milano 1960), p. 4

P. Dustin, Nature 159. 794 (1947)

F. Toffoli, G. Gatti, Boll. Chim. Lab. Provo 1 (26) (1) 99 (1975)

g. s. Chimica Industria 58 (3) 234 (1976)

M. R. Osborne in: Searle. 2a ed ., vol. 1, cap. 8, p. 485-516

C. Toffoli et al., Boll. Chim. Farmac. 120. 253 (1981);F. Toffoli, A. Oderio, Farmacia e Clinica (Roma) 25 (2) 95 (1986)

F. Toffoli, A. Oderio, Farmacia e Clinica (Roma) 25 (2) 95 (1986)

Chem. Brit. 21.6.1985, p.513. Da: Chimica Industria 67 (11) 652 (1985)

Y.T. Chen et al., Eur. J.Biochem. 122, 361-368 (1982)

F.Vogel, L. Lumper, Biochem. J. 236, 871 (1986)

R.G.Croy et al. in: Organ and Species Specificity in Chemical Carci­nogenesis. Basic Life Sciences N. 24 (Plenum Press, New York 1983) p.49-60

J.K. Selkirk et al., ibidem p. 283-294

D.W. Gaylor et al., Environm. Pathol. Toxicol. Oncol. 6, 127 (1985)

C.J. Omiecinski, M.R. Jucahau, "Microsomes. Drug Oxidation and Chemical Carcinogenesis". Ed. J. Coon et al. Vol. II (Acad. Press 1980) p. 969

N. Nemoto, S. Takayama, Gann 73, 887 (1982)

B. Weinstein, Science 209, 297-299 (1980)

L. Jack, P. Brooks, Nucleic Acids Res. 9, 5533-52 (1981)

M.S. Kulkarni, M.W. Anderson, Cancer Res. 44, 97-101 (1984)

R.G.Croy et al. in: Organ and Species Specificity in Chemical Carci­nogenesis. Basic Life Sciences N. 24 (Plenum Press, New York 1983) p.49-60

F.B. Daniel et al. Cancer Res. 43, 4723-29 (1983)

M.E. Hoffman et al., Biochim. Biophys. Acta 781. 234-38 (1984)

A. Tanook, K. Tanaka, Cancer Res. 42,1856-58 (1982)

BIBRA experts editorial, Food Chem. Toxicol. 22, 323 (1984)

E.C. Miller, Cancer Res. 38, 1479 (1978)

W.K. Lutz, Mutat. Res. 65,289-356 (1979)

W.K. Lutz in: Adv. Exp. Med. Bioi. 136. Pt B 1349-65 (1981)

K. Randerath et al., Environm. Health Persp. 62, 57 (1985)

C. Nicolini, Biophysics and Cancer (Plenum Press, 1986) p. 142-145

G.L. Gatti, F. Toffoli, Boll. Chim. Farmac. 117,64 (1978)

G. Theall et al. in: Banbury Report 13 "Indicators of Genotoxic Exposure". Ed. B.A. Bridges et al. (Cold Spring Harbor 1982) p. 231-240

B.S. Appleton et al. Cancer Res. 42, 3659-62 (1982)

B.P. Dunn, Cancer Res. 43,2654-58 (1983)

F. Toffoli, GL. Gatti, Boll. Chimici Lab. Provo 1 (26) (1) 99 (1975)

GL. Gatti, F. Toffoli, ibidem 3 (28) (11) 309 (1977); GL. Gatti, F. Toffoli, Boll. Chim. Farmac.117, 64 (1978)

B.E. Butterworth et al., Carcinogenesis 5, 1329 (1984)

E. Schacter et al., Carcinogenesis 9, 2297 (1988)

A.J. Saladino, Cancer Res. 45, 2522 (1985)

R.H. Purdy, M.V. Marshall, Carcinogenesis 5,1709-15 (1984)

B.E. Henderson et al., Cancer Res. 48,246 (1988)

C. Sumi et al., J. Nat. Cancer Inst. 73, 1229 (1984)

B.K. Beyer, M.R. Juchau, Biochem. Biophys. Res. Comm. 145, 402 (1987)

S.A. Sundstrom et al., Biochem. Pharmacol. 37, 1003 (1988)

J.G. Liehr, Arch. Toxicol. 55, 119 (1984)

J.G. Liehr et al. Cancer Res. 48, 779 (1988)

J.G.Liehr et al., Proc. Nat. Acad. Sci. 83, 5301 (1986)

M. Melbye et al. J. Nat. Cancer Inst. 73, 1267 (1984)

American Council on Science and Health. Report 1995. A. Fellman: "Dioxin in the environment: its effect on human health. Da: L. Malatesta. Chimica Industria 67 (5) 245 (1985)

P. Mocarelli et.al., JAMA Italia 4 (2) 145 (1987); P. Mastroiacovo et. aI., JAMA 259 (11) 1668 (1988)

S. Arrhenius, Le leggi quantitative della chimica biologica (Sonzogno, Milano 1922)

C. H. Bamford, C. F. H. Tipper, Comprensive Chemical Kinetics, vol. 10 (Elsevier, Amsterdam 1972)

C. Walling, Free radicals in solution (J. Wiley, New York 1957)

S. W. Benson, Thermochemical Kinetics: Methods for estimation of thermochemical data and rate parameters (J. Wiley, New York 1968)

K. A. Connors, G. L. Amidon, L. Kennon, Chemical Stability of Pharmaceuticals (J. Wiley, New York 1979)

Fusco, vol.l°,p. 70-72

J. D. Cox, G. Pilcher, Thermochemistry of Organic and Organo-metallic Compounds (Acad. Press, London, New York 1970)

G. Leroy, Advances in Quantum Chemistry 17,48 (1985)

G. Leroy, J. of Molecular Structure 168 (Theo Chern 45) 77 (1988)

L. Pauling, La natura del legame chimico (Edizioni Italiane, Roma 1949), p. 49-64

Handbook of Chemistry and Physics, 60ma ed. (CRC-Press, Cleveland 1979-80) p. F-231

C. Walling, Free radicals in solution (J. Wiley, New York 1957)

R. J. Gillespie, Molecular Geometry (van Nostrand Reinhold Series in Inorganic Chemistry, London 1972) p.20

Dewar, p. 428

P. Mirone, Chimica Industria 67 (9), Boll. Div. Didattica p. 60 (1985)

Dewar, p. 219

J. Fehér, G. Csomos, A. Vereckei, Free Radical Reactions in Medicine (Springer, 1987)

F. Minisci, Chimica Industria 56 (4) 274 (1974)

Dewar, p. 47-50, 205-210, 247-248

S.A.Ali in: Analytical 12, p.97

L. C. Schroeter, T. Higuchi, J. Am. Pharm. Ass. 47,426 (1958)

C. H. Scheider in: Allergic, cap. 1, p. 19 (con bibliografia)


Si ringraziano tutti gli autori, scienziati, biologi, medici, oncologi, etc.. indicati per ogni dato espresso come fonte scientifica.

Grazie a tutti voi.


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